Sildenafil Citrate

CAS NO: 139755-83-2
Batch Molecular FormulaC22H30N6O4S
Batch Molecular Weight474.5764
Physical AppearanceWhite / Powder
SolubilitySlightly Soluble
StorageStore at RT
Batch Molecular Structure


Sexual dysfunction

  • The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus.


Sildenafil citrate is a medication primarily used to treat erectile dysfunction (ED), a condition in which a man has difficulty achieving or maintaining an erection sufficient for sexual activity. Sildenafil is also sometimes used to treat other medical conditions. Here are the key points about sildenafil citrate:

  1. Erectile Dysfunction: Sildenafil works by increasing blood flow to the penis, which helps men with ED achieve and sustain an erection when sexually stimulated. It is commonly known by its brand name, Viagra, although there are generic versions available as well.
  2. Pulmonary Arterial Hypertension (PAH): Sildenafil is also used to treat a condition called pulmonary arterial hypertension, which is high blood pressure in the arteries that supply blood to the lungs. In this context, it helps relax and dilate the blood vessels in the lungs, reducing the workload on the heart and improving exercise capacity.
  3. Raynaud’s Phenomenon: In some cases, sildenafil is used to treat Raynaud’s phenomenon, a condition in which blood flow to the fingers and toes is restricted, often due to cold or stress. Sildenafil can help dilate blood vessels and improve blood circulation.
  4. Altitude Sickness: There is ongoing research into the potential use of sildenafil for preventing and treating high-altitude pulmonary edema, a condition that can occur at high altitudes.

Sildenafil is generally taken orally as a tablet, with its effects typically starting within 30 to 60 minutes and lasting for several hours. It should be used under the supervision of a healthcare provider, and the dosage may vary based on the specific condition being treated. Like all medications, sildenafil can have side effects, and it may interact with other drugs, so it’s important to use it as directed by a healthcare professional. It’s also important to be aware of potential contraindications and precautions associated with its use, particularly for individuals with certain medical conditions or those taking nitrates (often used for chest pain or angina), which can interact with sildenafil and cause a dangerous drop in blood pressure.